Novel predictor markers for early differentiation between transienttachypnea of newborn and respiratory distress syndrome inneonates

摘要

Neonatal Respiratory Distress Syndrome (RDS) and Transient Tachypnea of newborn(TTN) are common similar neonatal respiratory diseases. Study the earlypredictor markers in differentiation between TTN and RDS in neonates. Aprospective case control study which was done in Neonatal Intensive Care Unit(NICU) of Tanta University Hospital (TUH) from September 2016 to March 2018.Three groups of neonates were included in the study: RDS group (45 neonates),TTN group (45 neonates), and control group (45 healthy neonates). There werestatistically significant difference (SSD) between our studied three groups asregard serum Malondialdehyde (MDA), Superoxide dismutase SOD, Lactatedehydrogenase (LDH), and blood PH and P-values were 0.001* forthese comparative parameters. The ROC curve of RDS cases revealed that the serumMDA Cut off, sensitivity and specificity were 1.87 mmol/L, 98%, 96%,respectively which had the highest sensitivity and specificity followed by theserum SOD then the serum LDH and lastly the blood PH while in TTN cases, theserum MDA Cut off, sensitivity and specificity were 0.74 mmol/L, 96%, 93%,respectively then the serum SOD then the serum LDH and lastly the blood PH.Serum MDA, SOD, LDH, and PH had a beneficial role as early predictors indifferentiation between TTN and RDS in neonates.