INT-015 Side-effects and treatment response to methotrexate associated with comorbidity in early rheumatoid arthritis

摘要

In Denmark approximately 0.7% (35,000) of the population is diagnosed with rheumatoid arthritis (RA). RA is a risk factor in the development of comorbidity, and comorbidities are not well managed in RA patients. AS well as being a first-line treatment of early RA, methotrexate (MTX) gives a 70% reduction in cardiovascular disease-caused mortalities, and if treatment exceeds 1 year, the general mortality risks are lowered by 60%. Discontinuation of MTX is therefore a bad outcome for RA. It remains unclear whether side-effects and treatment response to MTX is associated with comorbidity in early RA.