Potential Issues With Virtual Populations When Applied to Nonlinear Quantitative Systems Pharmacology Models

摘要

Quantitative systems pharmacology (QSP) models attempt to describe the pharmacological properties of a drug. Although there are a wide variety of structures (e.g., logic models, fuzzy logic) the most common is based on ordinary differential equations (ODEs). In this perspective, we explore two case studies that are based on nonlinear drug actions described by ODEs where we show that regions of the parameter space exist that result in model predictions of system responses that are unacceptable.