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PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer

机译：肿瘤微环境中的PD-L1 +树突细胞与结肠癌的良好预后和CD8 + T细胞浸润相关

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The prognostic value of tumor‐associated dendritic cells (DC) in colon cancer remains poorly understood. This may be in part due to the interchangeable expression of immunostimulatory and immunoinhibitory molecules on DC. Here we investigated the prognostic impact of CD11c+ DC co–expressing the immunoinhibitory molecule PD‐L1 and their spatial relationship with CD8+ T‐cells in patients treated for stage III colon cancer.

机译：结肠癌肿瘤相关树突细胞（DC）的预后价值仍然清晰。这可能部分是由于免疫刺激和免疫抑制分子上的DC上的可互换表达。在这里，我们研究了CD11C + DC共表达免疫抑制分子PD-L1的预后影响及其与CD8 + T细胞的空间关系，治疗III阶段结肠癌。

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期刊名称 Cancer Science
作者
Timothy J. Miller; Chidozie C. Anyaegbu; Tracey F. Lee‐Pullen; Lisa J. Spalding; Cameron F. Platell; Melanie J. McCoy;
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作者单位

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年(卷),期 2021(112),3
年度 2021
页码 1173–1183
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
CD8; colon cancer; dendritic cells; PD‐L1; T cells;

机译：CD8;结肠癌;树突细胞;PD-L1;T细胞;

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专利

1. High expression of CX3CL1 by tumor cells correlates with a good prognosis and increased tumor-infiltrating CD8+ T cells, natural killer cells, and dendritic cells in breast carcinoma [J] . ParkM.H., LeeJ.S., YoonJ.H. Journal of Surgical Oncology . 2012,第4期

机译：乳腺癌细胞中CX3CL1的高表达与良好的预后以及增加的乳腺癌浸润性CD8 + T细胞，自然杀伤细胞和树突状细胞相关
2. Therapeutic efficacy of antitumor dendritic cell vaccinations correlates with persistent Th1 responses, high intratumor CD8+ T cell recruitment and low relative regulatory T cell infiltration [J] . DriessensG., GordowerL., NuttinL., Cancer immunology, immunotherapy : . 2008,第12期

机译：抗肿瘤树突状细胞疫苗的治疗功效与持续的Th1反应，肿瘤内CD8 + T细胞募集高和相对调节性T细胞浸润低有关
3. Therapeutic efficacy of antitumor dendritic cell vaccinations correlates with persistent Th1 responses, high intratumor CD8+ T cell recruitment and low relative regulatory T cell infiltration [J] . Gregory Driessens, Laurence Gordower, Lise Nuttin, Cancer Immunology, Immunotherapy . 2008,第12期

机译：抗肿瘤树突状细胞疫苗的治疗功效与持续的Th1反应，肿瘤内CD8 + T细胞募集高和相对调节性T细胞浸润低有关
4. IMMUNIZATION OF DENDRITIC CELLS PULSED WITH PRRS VIRUS GP5 PROTEIN INDUCES CD4+ BUT NOT CD8+ T CELLS [C] . Nguyen-Dinh Quat, Jeongran Min, Jiwon Han, Congress ofthe International Pig Veterinary Society . 2008

机译：用PRRS病毒GP5蛋白脉冲树突细胞的免疫诱导CD4 +但不是CD8 + T细胞
5. Super-charged NK cells increase immune infiltration in the tumor microenvironment and inhibit tumor growth in humanized-BLT mice. [D] . Kaur, Kawaljit. 2017

机译：荷电的NK细胞增加了肿瘤微环境中的免疫浸润，并抑制了人源化BLT小鼠的肿瘤生长。
6. Plasmacytoid Dendritic Cell (pDC) Infiltration Correlate with Tumor Infiltrating Lymphocytes Cancer Immunity and Better Survival in Triple Negative Breast Cancer (TNBC) More Strongly than Conventional Dendritic Cell (cDC) [O] . Masanori Oshi, Stephanie Newman, Yoshihisa Tokumaru, 2020

机译：血浆骨质树突细胞（PDC）浸润与肿瘤浸润淋巴细胞癌症免疫和在三重阴性乳腺癌（TNBC）中更好地存在的浸润性比常规树突细胞（CDC）更强烈
7. PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer [O] . Timothy J. Miller, Chidozie C. Anyaegbu, Tracey F. Lee‐Pullen, 2021

机译：肿瘤微环境中的PD-L1 +树突细胞与结肠癌的良好预后和CD8 + T细胞浸润相关

PD‐L1+ dendritic cells in the tumor microenvironment correlate with good prognosis and CD8+ T cell infiltration in colon cancer

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