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Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches

机译:Incetin激素和2型糖尿病 - 机械洞察力和治疗方法

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摘要

When we ingest a meal, our intestine secretes hormones that are released into the bloodstream. Amongst these hormones are the incretins hormones which stimulate the release of insulin from the pancreas which is essential for the regulation of in particular postprandial glucose concentrations. In patients with type 2 diabetes, the effect of the incretins is diminished. This is thought to contribute importantly to the pathophysiology of the disease. However, in pharmacological amounts, the incretins may still influence insulin secretion and metabolism. Much research has therefore been devoted to the development of incretin-based therapies for type 2 diabetes. These therapies include compounds that strongly resemble the incretins, hereby stimulating their effects as well as inhibitors of the enzymatic degradation of the hormones, thereby increasing the concentration of incretins in the blood. Both therapeutic approaches have been implemented successfully, but research is still ongoing aimed at the development of further optimized therapies.
机译:当我们摄取一顿饭时,我们的肠道分泌释放到血液中的激素。在这些激素中是刺激来自胰腺胰岛素的胰岛素的胰蛋白酶,这对于特别是对药物葡萄糖浓度的调节至关重要。在患有2型糖尿病的患者中,Incetetins的效果降低。这被认为是促进疾病的病理生理学的重要贡献。然而,在药理量中,Incetins仍可能影响胰岛素分泌和代谢。因此,对2型糖尿病的基于Incetin的疗法进行了许多研究。这些疗法包括强烈类似于Incetins的化合物,特此刺激它们的效果以及激素的酶促劣化的抑制剂,从而增加血液中Incetins的浓度。两种治疗方法都已经成功实施,但研究仍然旨在旨在开发进一步优化的疗法。

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