首页> 外国专利> PHARMACEUTICAL PRODUCT TO INDUCE ENDOGENOUS EXACERBATED RELEASE OF GUT HORMONES PYY AND GLP1 WITH THERAPEUTIC EFFECT ON OBESITY AND TYPE 2 DIABETES MELLITUS

PHARMACEUTICAL PRODUCT TO INDUCE ENDOGENOUS EXACERBATED RELEASE OF GUT HORMONES PYY AND GLP1 WITH THERAPEUTIC EFFECT ON OBESITY AND TYPE 2 DIABETES MELLITUS

机译:药物产品可诱导肠道激素PYY和GLP1内源性过度释放,对肥胖症和2型糖尿病的治疗作用

摘要

The present invention concerns a pharmaceutical product to induce endogenous exacerbated release of gut hormones, pyy and glp1, with therapeutic effect on obesity and type 2 diabetes mellitus. In tablets form, suitable dosage forms such as pills capable of disintegration from a certain range of Ph or specific Ph range between 6.0 and 7.0, so that the undigested or partially hydrolyzed content is released in the distal jejunum and preferably in the ileum/proximal colon. And by contact with macro-nutrient molecules, or their hydrolyzed fragments, such cells suffer intense amplified stimulus and secrete the said hormones, released at rates that are therapeutics for obesity of any degree and also for type II diabetes; mimicking that produced and performed in bariatric and metabolic surgeries by a noninvasive method.
机译:本发明涉及一种药物产品,其诱导内源性肠道激素,pyy和glp1的加剧释放,对肥胖症和2型糖尿病具有治疗作用。在片剂形式中,合适的剂型,例如能够在一定范围内的PH或6.0至7.0范围内的特定PH崩解的丸剂,使得未消化或部分水解的成分释放到空肠远端,优选回肠/近端结肠。通过与大量营养分子或它们的水解片段接触,这些细胞受到强烈的刺激并分泌所述激素,这些激素的释放速率可治疗任何程度的肥胖症,也可治疗II型糖尿病。通过无创方法模仿在肥胖症和代谢外科手术中产生和进行的活动。

著录项

  • 公开/公告号US2014377353A1

    专利类型

  • 公开/公告日2014-12-25

    原文格式PDF

  • 申请/专利权人 GILBERTO BORGES DE BRITO;

    申请/专利号US201313924984

  • 发明设计人 GILBERTO BORGES DE BRITO;

    申请日2013-06-24

  • 分类号A61K9/50;A61K9/28;A61K31/575;A61K31/702;A61K31/715;A61K31/20;A61K38/16;A61K31/23;

  • 国家 US

  • 入库时间 2022-08-21 15:22:17

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