Effectiveness and safety of hFVIII/VWF concentrate (Voncento

机译：HFVIII / VWF精矿的有效性和安全性（迁移

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In patients with moderate to severe qualitative and quantitative von Willebrand disease (VWD), even minor surgical procedures can be associated with a risk of life-threatening bleeding. Treatment strategies vary according to the levels of von Willebrand factor (VWF) and Factor VIII (FVIII). The aim of this study was to evaluate the effectiveness and the safety of Voncento® (CSL Behring, Marburg, Germany), a plasma-derived FVIII/VWF concentrate (ratio 1:2.4), during surgeries performed in patients with inherited VWD.

机译：在中度至严重定性和定量von Willebrand疾病（VWD）的患者中，甚至轻微的外科手术也可能与危及生命的出血的风险有关。治疗策略根据von Willebrand因子（VWF）和因子VIII（FVIII）的水平而变化。本研究的目的是评估迁徙患者遗传性VWD患者进行的血浆衍生的FVIII / vWF浓缩物（比率1：2.4）的血管生成®（CSL Behring，Marburg，德国）的有效性和安全性。

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期刊名称 Blood Transfusion
作者
Lucia Rugeri; Roseline d’Oiron; Annie Harroche; Valérie Proulle; Guillaume Mourey; Emmanuelle De Raucourt; Dominique Desprez; Nathalie Itzhar Baikian; Brigitte Pan Petesch; Annie Borel-Derlon; Sophie Combe; Birgit Frotscher; Abel Hassoun; Hasan Catovic; Diane Bracquart; Marc Trossaërt;
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作者单位

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年(卷),期 2021(19),2
年度 2021
页码 152–157
总页数 6
原文格式 PDF
正文语种
中图分类血液学检验;
关键词
bleeding; von Willebrand disease; surgery; FVIII/VWF concentrates; Voncento;

机译：出血;von willebrand疾病;手术;fviii / vwf浓缩物;voncento;

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专利

1. Pharmacokinetics, efficacy, and safety of a plasma-derived VWF/FVIII concentrate (VONCENTO) for on-demand and prophylactic treatment in patients with von Willebrand disease (SWIFT-VWD study) [J] . Lissitchkov Toshko J., Buevich Evgeny, Kuliczkowski Kazimierz, Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis . 2017,第2期

机译：血浆衍生的VWF / FVIII浓缩物（迁移率为von Willebrand疾病患者的按需和预防治疗的药代动力学，疗效和安全性（SWIFT-VWD研究）
2. Efficacy, safety and pharmacokinetic profiles of a plasma-derived VWF/FVIII concentrate (VONCENTO (R)) in subjects with haemophilia A (SWIFT-HA study) [J] . Skotnicki Aleksander, Lissitchkov Toshko J., Mamonov Vasily, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第1期

机译：血浆来源的VWF / FVIII浓缩物（VONCENTO（R））在A型血友病患者中的功效，安全性和药代动力学概况（SWIFT-HA研究）
3. Efficacy, safety and pharmacokinetic profiles of a plasma-derived VWF/FVIII concentrate (VONCENTO (R)) in subjects with haemophilia A (SWIFT-HA study) [J] . Skotnicki Aleksander, Lissitchkov Toshko J., Mamonov Vasily, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2016,第1期

机译：血浆衍生的VWF / FVIII浓缩物（Voncento（R））中血肠道A的疗效，安全性和药代动力学谱（SWIFT-HA研究）
4. An FⅧ-derived Peptide Enables VWF-binding of an Artificial Platelet Substitute without Interfering with Natural Platelet Adhesion to VWF [C] . Christa L. Modery-Pawlowski, Hassan Haji-Valizadeh, Anirban Sen Gupta Society for Biomaterials annual meeting and exposition . 2014

机译：F F肽使人工血小板替代物的VWF结合而不会干扰天然血小板对VWF的粘附
5. The Effectiveness of Natural Organic Matter in Concentrating Metals. Part I. Adsorption of Copper by Peat, Lignite, and Bituminous Coal. Part II. Translocation and Immobilization of Metals in Humus Solution [D] . Ong, Han-Ling. 1967

机译：天然有机物在浓缩金属中的有效性。第一部分：泥炭，褐煤和烟煤对铜的吸附。第二部分腐殖质溶液中金属的移位和固定
6. Pharmacokinetics efficacy and safety of a plasma-derived VWF/FVIII concentrate (VONCENTO) for on-demand and prophylactic treatment in patients with von Willebrand disease (SWIFT-VWD study) [O] . Toshko J. Lissitchkov, Evgeny Buevich, Kazimierz Kuliczkowski, -1

机译：血浆源性VWF / FVIII浓缩物（VONCENTO）在von Willebrand病患者中按需和预防性治疗的药代动力学功效和安全性（SWIFT-VWD研究）
7. Efficacy, Safety and Pharmacokinetic Results of a Phase III, Open-Label, Multicenter Study with a Plasma-Derived Von Willebrand Factor (VWF)/Factor VIII (FVIII) Concentrate in Pediatric Patients [O] . Claudia Djambas Khayat, Genadi Iosava, Irina Romashevskaya, 2021

机译：III期，开放标签，多中心研究的疗效，安全性和药代动力学结果与血浆衍生的von Willebrand因子（VWF）/因子VIII（FVIII）浓缩在儿科患者中
8. Influence of Factor VIII/von Willebrand Factor Protein (F VIII/vWF) and F VIII/vWF-Poor Cryoprecipitate on Post-Ischemic Microvascular Reperfusion in the Central Nervous System [R] . Hallenbeck, J. M., Furlow, T. W., Gralnick, H. R. 1980

机译：因子VIII / von Willebrand因子蛋白（F VIII / vWF）和F VIII / vWF-差冷沉淀物对中枢神经系统缺血后微血管再灌注的影响

Effectiveness and safety of hFVIII/VWF concentrate (Voncento

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