An FⅧ-derived Peptide Enables VWF-binding of an Artificial Platelet Substitute without Interfering with Natural Platelet Adhesion to VWF

摘要

Decoration with the FⅧ-derived VBP can render stable VWF-adhesion of artificial platelet constructs by a mechanism distinct from platelet GPIba interaction with VWF's A1 domain. This adhesion is possibly through VWF's D'-D3 domain.