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Self-microemulsifying drug delivery system (SMEDDS) of curcumin attenuates depression in olfactory bulbectomized rats

机译：姜黄素的自我乳化药物递送系统（SMEDDS）在嗅到血糖瘤症中的抑郁症

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摘要

Current therapies for depression remain limited and plagued by various side effects. Problems associated with curcumin administration include poor aqueous solubility and bioavailability issues. Hence to overcome these, curcumin self micro emulsifying drug delivery system (SMEDDS) which will result in a nanosize emulsion droplets when administered were formulated in the present study.

机译：目前的抑郁疗法仍然受到各种副作用的限制和困扰。与姜黄素给药相关的问题包括差的含水溶解度和生物利用度问题。因此，在本研究中配制时，将克服这些，将导致纳米化乳液液滴的姜黄素自微微乳化药物递送系统（SMEDDS）。

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期刊名称 Heliyon
作者
Manoj Aswar; Mangesh Bhalekar; Akshata Trimukhe; Urmila Aswar;
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作者单位

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年(卷),期 2020(6),8
年度 2020
页码 -1
总页数 8
原文格式 PDF
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关键词
Pharmaceutical science; Pharmacology; Toxicology; Depression; Curcumin; Olfactory bulbectomy; SMEDDS;

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专利

1. Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer [J] . Desai Preshita, Thakkar Arvind, Ann David, Drug delivery and translational research . 2019,第3期

机译：LorataDine自我微乳化药物递送系统（SMEDDS）与Sulforaphane组合用于胰腺癌的协同化学预防
2. Effects of Spray-Drying and Choice of Solid Carriers on Concentrations of Labrasol~R and Transcutol~R in Solid Self-Microemulsifying Drug Delivery Systems (SMEDDS) [J] . Liang Li, Tao Yi, Christopher Wai-Kei Lam Molecules . 2013,第1期

机译：喷雾干燥和固体载体的选择对固体自微乳化药物递送系统（SMEDDS）中Labrasol〜R和Transcutol〜R浓度的影响
3. Effects of Spray-Drying and Choice of Solid Carriers on Concentrations of Labrasol? and Transcutol? in Solid Self-Microemulsifying Drug Delivery Systems (SMEDDS) [J] . Molecules . 2013,第1期

机译：喷雾干燥和固体载体的选择对拉布拉索尔浓度的影响？和Transcutol？固体自微乳化药物递送系统（SMEDDS）的研究
4. Resveratrol Loaded Self-Microemulsifying Drug Delivery System (SMEDDS): Development and Optimization [C] . Liu Guoqing, Zhou Huafeng, Zhang Jing, International Conference on Materials Science and Engineering Technology . 2014

机译：白藜芦醇负载自我微乳化药物递送系统（SMEDDS）：开发和优化
5. Development and characterization of a solid self-microemulsifying drug delivery system (SMEDDS) of albendazole and evaluation of oral bioavailability in rabbits. [D] . Mukherjee, Tusharmouli. 2010

机译：阿苯达唑固体自微乳化药物递送系统（SMEDDS）的开发和表征以及兔口服生物利用度的评估。
6. A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against Depression: a Preparation and Bioavailability Study in Rats [O] . Lan Wu, Yanli Qiao, Lina Wang, 2015

机译：一种新型抗抑郁药的自微乳化药物递送系统（SMEDDS）：大鼠的制备和生物利用度研究
7. Self-microemulsifying drug delivery system (SMEDDS) of curcumin attenuates depression in olfactory bulbectomized rats [O] . Manoj Aswar, Mangesh Bhalekar, Akshata Trimukhe, 2020

机译：姜黄素的自我乳化药物递送系统（SMEDDS）在嗅到血糖瘤症中的抑郁症

Self-microemulsifying drug delivery system (SMEDDS) of curcumin attenuates depression in olfactory bulbectomized rats

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