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White matter microstructure in athletes with a history of concussion: Comparing diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI)

机译:具有脑震荡史的运动员的白质微观结构:比较弥散张量成像(DTI)和神经突方向弥散与密度成像(NODDI)

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摘要

Sport concussion is associated with disturbances in brain function in the absence of gross anatomical lesions, and may have long‐term health consequences. Diffusion‐weighted magnetic resonance imaging (MRI) methods provide a powerful tool for investigating alterations in white matter microstructure reflecting the long‐term effects of concussion. In a previous study, diffusion tensor imaging (DTI) showed that athletes with a history of concussion had elevated fractional anisotropy (FA) and reduced mean diffusivity (MD) parameters. To better understand these effects, this study compared DTI results to neurite orientation dispersion and density imaging (NODDI), which was used to estimate the intracellular volume fraction ( ) and orientation dispersion index (ODI). Sixty‐eight (68) varsity athletes were recruited, including 37 without a history of concussion and 31 with concussion >6 months prior to imaging. Univariate analyses showed elevated FA and decreased MD for concussed athletes, along with increased and reduced ODI, indicating greater neurite density and coherence of neurite orientation within white matter. Multivariate analyses also showed that for athletes with a history of concussion, white matter regions with increased FA had increased and decreased ODI, with greater effects among athletes who were imaged a longer time since their last concussion. These findings enhance our understanding of the relationship between the biophysics of water diffusion and concussion neurobiology for young, healthy adults. . ©
机译:在没有严重的解剖病变的情况下,脑震荡与脑功能紊乱有关,并且可能对健康产生长期影响。弥散加权磁共振成像(MRI)方法为研究反映脑震荡长期影响的白质微观结构变化提供了强大的工具。在先前的研究中,扩散张量成像(DTI)表明具有脑震荡史的运动员分数各向异性(FA)升高,平均扩散系数(MD)参数降低。为了更好地了解这些效应,本研究将DTI结果与神经突取向分散和密度成像(NODDI)进行了比较,后者用于估算细胞内体积分数( )和方向分散指数(ODI)。招募了六十八(68)名大学运动员,其中37名无脑震荡史,31名脑震荡≥6个月。单因素分析显示,脑震荡运动员的FA升高,MD降低,同时增加 降低的ODI,表明白质内神经突密度更高,神经突取向相干性更高。多变量分析还显示,对于有脑震荡史的运动员,FA增加的白质区域增加 自从上次脑震荡起拍摄的时间更长,对运动员的影响更大。这些发现增强了我们对年轻健康成年人水扩散生物物理学与脑震荡神经生物学之间关系的理解。 。 ©

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