Tacrolimus-induced gingival hyperplasia and recovery from tacrolimus to everolimus switching

摘要

A 28-year-old female patient presented with a complaint of gingival hyperplasia (GH). The patient has diagnosed with chronic renal failure due to focal segmental glomerulosclerosis. She had a renal transplant eight months before admission to our hospital. The patient was using tacrolimus (TcR) 9 g/day, mycophenolate mofetil 720 mg/day, prednisolone 5 mg/day, lansoprazol 40 mg/day. She did not use nifedipine or phenytoin. Physical examination revealed GH ( ), but there were no other pathologies. General systemic examination and laboratory tests were normal. The blood TcR level was 11 ng/ml (normal range: 5–20 ng/ml). TcR was interrupted and switched to everolimus. It was observed that GH improved after one month in the outpatient clinic ( ).