Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy

摘要

Need for MRI in HIE-related clinical trials. Each icon notes a hospital/site where at least one HIE-related clinical trial is ongoing. Red icons are hospitals that use MRI and blue icons are those that do not use MRI in their trials. Among 108 ongoing clinical trials pertaining to HIE at hospitals from 33 countries in 5 continents, roughly half of the hospitals use MRI as part of their trials, highlighting the widespread need for MRI biomarkers that can detect HIE lesions at infancy and predict HIE outcomes at 2 years of age. This figure was created based on searching the key word “Hypoxic Ischemic Encephalopathy” in the public website for clinical trial registries ( ). The search was in June 2019. We manually added each site in all 108 resulting HIE trials on the Google My Map website