BIOFLUID-BASED PROTEIN AND MIRNA BIOMARKERS FOR NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY

摘要

The invention relates to a combination or panel of HIE -relevant protein and/or microRNA (miRNA) biomarkers that are released from injured tissues into biofluids such as blood in HIE, and their use as markers for detection of HIE. A selected panel of blood-based protein and/or miRNA HIE biomarkers that are measured at more than one time interval can aid in the diagnosis of HIE severity, and to determine the prognosis of poor versus good cognitive or overall patient outcome.