LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation

摘要

Identification and verification of DEPs in ESCC tissues. Paired ESCC and adjacent normal esophageal tissues from three patients were analyzed by TMT. Twofold change was defined as the threshold for a significant change in expression. We detected 39 proteins up-regulated in cancer tissues compared with that in adjacent normal tissues (paired-samples t-test, p b Gene ontology enrichment analysis of identified DEPs which were classified into cellular component, molecular function, and biological process. , Validation of DEPs in ESCA. The expression of FN1, LTBP1, PLOD2, THBS1 and RCN3 were confirmed by GEPIA and western blot analysis. non-tumorous tissues, tumorous tissues. (one-way ANOVA and paired-samples t-test, *p