PLAU directs conversion of fibroblasts to inflammatory cancer-associated fibroblasts promoting esophageal squamous cell carcinoma progression via uPAR/Akt/NF-κB/IL8 pathway

摘要

A, B PLAU was more highly expressed in cancer compared with para-cancer tissues at the RNA (A, {"type":"entrez-geo","attrs":{"text":"GSE53625","term_id":"53625"}}GSE53625) and protein (B, C) levels, B western blot analysis of tumor and adjacent nontumor tissues from five patients, and C immunohistochemistry (IHC) scores (left) and representative images (right) of PLAU staining in ESCC tumor tissues and nontumor tissues (original magnification: 50×, 200×). D, E Kaplan–Meier survival analysis of overall survival based on high (n = 89) and low (n = 90) PLAU expression in {"type":"entrez-geo","attrs":{"text":"GSE53625","term_id":"53625"}}GSE53625 (D) and high (n = 34) and low (n = 11) PLAU expression by IHC (E). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (Student’s t-test or).