KLF13 suppresses the proliferation and growth of colorectal cancer cells through transcriptionally inhibiting HMGCS1-mediated cholesterol biosynthesis

摘要

KLF13 is downregulated in CRC tissues. KLF13 transcript abundance in colorectal normal tissues (n = 51) and CRC tissues (n = 647) from TCGA database. ***p b RT-qPCR analysis of KLF13 mRNA expression in colorectal normal tissues (n = 24) and RC tissues (n = 30). ***p c, Western blot analysis of KLF13 protein expression in colorectal adjacent normal tissues (n = 6) and CRC tissues (n = 6). Western blot images. Quantification of the protein level. **p e, Western blot ( ) and RT-qPCR ( ) analysis of KLF13 in NCM460, HT-29, HCT116 and SW480 cells. *p