Comparing copy-number profiles under multi-copy amplifications and deletions

摘要

Cancer is widely recognized as an evolutionary process during which cells within a population accumulate aberrant somatic mutations and replicate indefinitely [ ]. These cells are divided in subpopulations, called , that share common mutation traits and form tumors. A natural problem that arises is to reconstruct the evolution of a set of clones within a tumor. This question has recently led to the development of several phylogenetic algorithms tailored for cancer evolution. Most of them use either information of single nucleotide variants obtained from bulk [ – ] or single-cell [ – ] sequencing data, or copy-number alterations [ – ] (usually in the context of single-cell data). We refer the reader to [ ] for a survey of these methods.