Identifying miRNA synergism using multiple-intervention causal inference

摘要

The workflow of miRsyn. The process contains three main steps. Firstly, we identify significant miRNAs and mRNAs using feature selection from miRNA and mRNA expression data. Secondly, by integrating expression data of significant miRNAs and mRNAs and putative miRNA-target interactions, we identify miRNA synergistic network and modules. Finally, we make a functional analysis of the identified miRNA synergistic network and modules