Necessity of guidelines for publication of patient-derived cancer models

摘要

Yu reported the establishment of novel patient-derived xenograft (PDX) and cell line (PDC) models of osteosarcomas, and demonstrated that these models can spontaneously metastasize to the lungs ( ). Patients with osteosarcomas often suffer from lung metastasis, therefore, the reported models can be useful resources for sarcoma research. Considering the diversity of this disease, models from a single case cannot provide definitive conclusions, and additional models from different cases are needed. In this sense, Yu ’s study can be considered an important part of the research community’s efforts, and the established models will contribute to research progress, especially if they are shared broadly. Recent comprehensive studies employed a large number of cell lines to integrate data on drug response and genetic information ( - ). Although the number of sarcoma cell lines in these large projects was relatively small, a novel association of mutated cancer genes with cellular responses to drugs was identified in sarcomas ( ). Novel cell lines of rare cancers, such as sarcomas, are useful resources for such studies, and the cell line reported by Yu has the potential to contribute to future sarcoma research ( ). However, both the xenograft and cell line reported in their paper have fundamental problems, which are discussed here.