首页> 外文会议>Molecular-Guided Surgery: Molecules, Devices, and Applications IV >Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model
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Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model

机译:荧光人源化抗CEA抗体在源自患者的原位异种移植(PDOX)小鼠模型中特异性标记转移性胰腺癌

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摘要

Specific tumor targeting can result in selective labeling of cancer in vivo for surgical navigation. In the present study, we show that the use of an anti-CEA antibody conjugated to the near-infrared (NIR) fluorescent dye, IRDye800CW, can selectively target and label pancreatic cancer and its metastases in a clinically relevant patient derived xenograft mouse model.
机译:特定的肿瘤靶向可以导致体内选择性标记癌症以进行手术导航。在本研究中,我们显示与近红外(NIR)荧光染料IRDye800CW偶联的抗CEA抗体的使用可以在临床相关的源自患者的异种移植小鼠模型中选择性靶向和标记胰腺癌及其转移。

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