The Incidence of Late Rectal Bleeding in High-Dose Conformal Radiotherapy of Prostate Cancer using EUD- and Dose-Volume Based NTCP Models

摘要

PurposeAccurate modelling of rectal complications based on DVH data is necessary to allow safe dose escalation in radiotherapy of prostate cancer. We applied different EUD- and dose-volume based NTCP models to rectal wall DVHs and follow-up data of 319 prostate cancer patients in order to identify the dosimetric factors most predictive for grade 2 or higher rectal bleeding.