Sorafenib Inhibits Growth and MAPK Signaling in Malignant Peripheral Nerve Sheath Cells

摘要

PurposeMalignant peripheral nerve sheath tumors (MPNSTs) are soft tissue tumors with a very poor prognosis and largely resistant to chemotherapy. MPNSTs are characterized by activation of the ras pathway by loss of tumor suppressor neurofibromatosis type I (NF1). In view of this MPNST may be susceptible to inhibition of the activated Ras/Raf/MAPK pathway by the B-Raf inhibitor sorafenib.