TREATMENT OF MALIGNANT PERIPHERAL NERVE SHEATH TUMORS BY TARGETING APE1/REF-1 TO INHIBIT HYPOXIA SIGNALING GENES

摘要

Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APE1/Ref-1) are disclosed. More particularly, methods for inhibiting APE1/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.