PET Imaging of D2/3 agonist binding in healthy human subjects with the radiotracer 11C-N-propyl-nor-apomorphine (NPA): preliminary evaluation and reproducibility studies

摘要

Objective(-)-N-[¹¹C]-Propyl-norapomorphine (NPA) is a full dopamine D2/3 receptor agonist radiotracer suitable for imaging D2/3 receptors configured in a state of high affinity for agonists using Positron Emission Tomography (PET). The aim of the present study was to define the optimal analytic method to derive accurate and reliable D2/3 receptor parameters with [¹¹C]NPA.