Coupled plasmon aveguide resonance studies of agonist/antagonist binding to the human delta-opioid receptor provide new structural insights into the three-state model for receptor-ligand interactions

摘要

Traditional methods in pharmacology characterize a ligand by its binding to a receptor and/or the subsequent second messenger response.No information on the direct conformation changes to the receptor in response to the ligand is obtained.Using a new method,coupled plasmon-waveguide resonance spectroscopy,structural changes of the human delta-opioid receptor immobilized in a lipid bilayer accompanying the binding of agonists and antagonists have been investigated.