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Identification of the Promoter of Human Carbonyl Reductase 3 (CBR3) and Impact of Common Promoter Polymorphisms on Hepatic CBR3 mRNA Expression

机译：鉴定人羰基还原酶3（CBR3）的启动子及常见启动子多态性对肝CBR3 mRNA表达的影响

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PurposeRecent studies suggest that polymorphisms in human carbonyl reductase 3 (CBR3) influence the pharmacodynamics of doxorubicin. First, we sough to identify the promoter of CBR3. Next, we examined whether two CBR3 promoter polymorphisms (CBR3 -725T>C and CBR3 -326T>A) dictate promoter activity and hepatic CBR3 mRNA levels.

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期刊名称 other
作者
Jianping Zhang; Javier G. Blanco;
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年(卷),期 -1(26),9
年度 -1
页码 2209–2215
总页数 14
原文格式 PDF
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关键词
carbonyl reductase 3 (CBR3) gene promoter single nucleotide polymorphism ethnicity liver;

机译：羰基还原酶3（CBR3）;基因启动子;单核苷酸多态性;种族;肝脏;

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专利

1. Identification of the Promoter of Human Carbonyl Reductase 3 (CBR3) and Impact of Common Promoter Polymorphisms on Hepatic CBR3 mRNA Expression [J] . Jianping Zhang, Javier G. Blanco Pharmaceutical Research . 2009,第9期

机译：人类羰基还原酶3（CBR3）启动子的鉴定和常见启动子多态性对肝CBR3 mRNA表达的影响。
2. Identification of the promoter of human carbonyl reductase 3 (CBR3) and impact of common promoter polymorphisms on hepatic CBR3 mRNA expression. [J] . Zhang J, Blanco JG Pharmaceutical research . 2009,第9期

机译：人羰基还原酶3（CBR3）启动子的鉴定以及常见启动子多态性对肝CBR3 mRNA表达的影响。
3. A conserved antioxidant response element (ARE) in the promoter of human carbonyl reductase 3 (CBR3) mediates induction by the master redox switch Nrf2. [J] . Cheng Q, Kalabus JL, Zhang J, Biochemical Pharmacology . 2012,第1期

机译：人羰基还原酶3（CBR3）启动子中的保守抗氧化剂响应元件（ARE）介导主氧化还原开关Nrf2诱导。
4. MALDI TOF/TOF Identification of Alkylation Sites In Recombinant Carbonyl Reductase Inactivated by Electrophilic Metabolites of a Lung Tumor Promoter [C] . Kristofer S. Fritz, Colin T. Shearn, Jose D. Gomez, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：通过肺肿瘤启动子亲电子代谢产物灭活重组羰基还原酶烷基化位点的MALDI TOF / TOF鉴定
5. TNF promoter polymorphisms associated with skeletal muscle phenotypes in humans. [D] . Liu, Dongmei. 2008

机译：与人类骨骼肌表型相关的TNF启动子多态性。
6. A Conserved Antioxidant Response Element (ARE) in the Promoter of Human Carbonyl Reductase 3 (CBR3) Mediates Induction by the Master Redox Switch Nrf2 [O] . Qiuying Cheng, James L. Kalabus, Jianping Zhang, -1

机译：一个保守的抗氧化反应元件（aRE）的人类羰基还原酶3（CBR3）介导诱导的由主氧化还原开关Nrf2的启动子
7. Identification of the Promoter of Human Carbonyl Reductase 3 (CBR3) and Impact of Common Promoter Polymorphisms on Hepatic CBR3 mRNA Expression [O] . Jianping Zhang, Javier G. Blanco 2009

机译：鉴定人羰基还原酶3（CBR3）的启动子及常见启动子多态性对肝CBR3 mRNA表达的影响

Identification of the Promoter of Human Carbonyl Reductase 3 (CBR3) and Impact of Common Promoter Polymorphisms on Hepatic CBR3 mRNA Expression

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