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THERAPEUTIC ISSUES IN THE TREATMENT OF VASCULARIZED XENOTRANSPLANTS USING GAL-KNOCKOUT DONORS IN NONHUMAN PRIMATES

机译：治疗血管化异种塑料的治疗问题在非人的加仑制灵流淘汰贷款人

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摘要

Purpose of reviewSolid organ xenotransplantation could be the future of transplantation, but improved outcomes are required in experimental models before clinical trials are justified. This review summarizes recent advances in solid organ xenotransplantation using organs from α1,3-galactosyltransferase gene-knockout (GTKO) pigs (with or without other genetic modifications) and novel therapeutic approaches.

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期刊名称 other
作者
Burcin Ekser; Goutham Kumar; Massimiliano Veroux; David K.C. Cooper;
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年(卷),期 -1(16),2
年度 -1
页码 222–230
总页数 15
原文格式 PDF
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关键词
α13-galactosyltransferase gene-knockout complement-regulatory proteins organs xenotransplantation;

机译：α13-半乳糖基转移酶基因敲除;补体调节蛋白;器官;异种移植;

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专利

1. Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates. [J] . Ekser B, Kumar G, Veroux M, Current opinion in organ transplantation . 2011,第2期

机译：在非人类灵长类动物中使用gal敲除供体治疗血管化异种移植的治疗问题。
2. Nonhuman primate model of fibula vascularized composite tissue allotransplantation demonstrates donor-recipient bony union. [J] . Mundinger GS, Nam AJ, Hui Chou HG, Plastic and reconstructive surgery . 2011,第6期

机译：非人类灵长类动物腓骨血管化复合组织同种异体移植模型表明供体-受体骨结合。
3. Therapeutic monoclonal antibody treatment protects nonhuman primates from severe Venezuelan equine encephalitis virus disease after aerosol exposure [J] . Crystal W. Burke, Jeffery W. Froude, Franco Rossi, PLoS Pathogens . 2019,第12期

机译：治疗性单克隆抗体治疗保护气溶胶暴露后严重委内瑞拉大当脑脑炎病毒疾病保护非人的灵长类动物
4. Evaluation of R_2* as a noninvasive endogenous imaging biomarker for Ebola virus liver disease progression in nonhuman primates [C] . Marcelo A. Castro, Ji Hyun Lee, Ian Crozier, Conference on Medical Imaging : Biomedical Applications in Molecular, Structural, and Functional Imaging . 2020

机译：r_2 *作为非洲原始工具中埃博拉病毒肝病进展的非侵入内源性成像生物标志物的评价
5. Effects of Alcohol and Acamprosate, an Alcohol Use Disorder Treatment, on Nonhuman Primate Behavior and Memory [D] . Johnson, Christopher A. 2019

机译：酒精和阿坎酸（一种酒精使用障碍治疗方法）对非人类灵长类动物行为和记忆的影响
6. Therapeutic monoclonal antibody treatment protects nonhuman primates from severe Venezuelan equine encephalitis virus disease after aerosol exposure [O] . Crystal W. Burke, Jeffery W. Froude, Franco Rossi, 2019

机译：单克隆抗体治疗性治疗可保护非人类灵长类动物免于暴露于气溶胶后的严重委内瑞拉马脑炎病毒疾病
7. Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates [O] . Burcin Ekser, Goutham Kumar, Massimiliano Veroux, 2011

机译：治疗血管化异种塑料的治疗问题在非人的加仑制灵流淘汰贷款人

THERAPEUTIC ISSUES IN THE TREATMENT OF VASCULARIZED XENOTRANSPLANTS USING GAL-KNOCKOUT DONORS IN NONHUMAN PRIMATES

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