Asthma is a distinct co-morbid condition in children with sickle cell anemia with elevated total and allergen-specific IgE levels

摘要

Asthma in children with sickle cell anemia (SCA) is associated with increased morbidity and mortality. However, the definition of asthma in SCA is based on a physician's impression. In a retrospective cohort of children with SCA, relationships between a physician diagnosis of asthma and total and allergen specific IgE levels were evaluated. In children with SCA, elevated total and specific IgE levels were significantly associated with a diagnosis of asthma (P<0.05), further supporting the concept that asthma is a separate co-morbid condition of SCA.