Synthesis and evaluation of 18FExendin (9-39) as a potential biomarker to measure pancreatic beta-cell mass

摘要

IntroductionGlucagon-like peptide 1 (GLP-1) is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Exendin (9-39), a potent GLP-1R antagonist, has been labeled with In-111 for SPECT imaging. We report here the first radiosynthesis of [¹⁸F]exendin (9-39) ([¹⁸F]Ex(9-39)) and an evaluation of its potential as a biomarker for in vivo PET imaging of pancreatic β-cell mass (BCM) in rats.