Five-year risk of CIN3+ and cervical cancer for women with HPV-positive and HPV-negative high-grade Pap results

摘要

ObjectiveHigh-grade Pap results (e.g., AGC, ASC-H, and HSIL) predict high cancer risks, resulting in referral to colposcopy without HPV triage. However, new guidelines recommending cotesting for women 30 and older imply that clinicians will often receive the HPV test result concurrently for high-grade Pap results. We examined whether HPV testing provides useful risk stratification in this context.