Objective: To explore the clinical features and prognosis of human papilloma virus (HPV) negative and positive cervical cancer. Methods: 19 patients with HPV negative cervical cancer (HPV negative group) and 21 patients with HPV positive cervical cancer (HPV positive group) were selected, FIGO clinical stage ⅠA to ⅡA patients were treated with surgery and PBF /PF chemotherapy, and patients with stage ⅡB to Ⅲ were given TC chemotherapy. The clinical pathological features of the two groups were compared. The distant metastasis free survival time of the two groups was followed up, and the short-term chemotherapy efficacy of the two groups of patients with stage ⅡB to Ⅲ was observed. Results: There was no significant difference in the longest diameter, pathological type and tumor appearance between HPV positive and negative cervical cancer (P＞0. 05 ). HPV positive and negative cervical cancer tissue differentiation, lymph node metastasis and myometrial invasion difference were statistically significant (P＜0.05). The short-term effective rate of HPV positive group and negative group was 64.29％ and 26.67％ respectively. The distant metastasis free survival time of HPV positive group was (16.65±0.98) months, which was significantly higher than that of HPV negative group (12.34±1.55) months. The difference was statistically significant (P＜0. 05). Conclusion: Comparing with HPV positive cervical cancer, HPV negative cervical cancer tends to be low differentiation, deep myometrial invasion and lymph node metastasis, and the prognosis is poor.%目的: 探讨人乳头状瘤病毒(HPV) 阴性和阳性宫颈癌的临床特点及预后情况.方法: 选取 HPV 阴性宫颈癌患者19 例(HPV 阴性组) 、HPV 阳性宫颈癌患者21 例(HPV 阳性组) ,FIGO 临床分期ⅠA～ⅡA 期患者给予手术和PBF /PF 化疗,ⅡB～Ⅲ期患者给予TC 化疗,比较两组临床病理特征,随访两组无远位转移生存时间以及观察两组ⅡB ～Ⅲ期患者近期化疗疗效.结果: HPV 阳性和阴性宫颈癌肿瘤最长径、病理类型和肿瘤外形比较差异无统计学意义(P＞0.05);HPV 阳性和阴性宫颈癌组织分化、淋巴结转移和肌层浸润比较差异有统计学意义(P＜0.05);HPV 阳性组和阴性组化疗近期有效率分别为64.29％和26.67％,两组比较差异有统计学意义(P＜0.05);HPV 阳性组无远位转移生存时间为(16.65±0.98) 个月,明显高于HPV 阴性组(12.34± 1.55) 个月,两组比较差异有统计学意义(P＜0.05).结论: 相比较HPV 阳性宫颈癌,HPV 阴性宫颈癌倾向于低分化、肌层浸润深和淋巴结转移,患者预后较差.
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