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VirusFinder: Software for Efficient and Accurate Detection of Viruses and Their Integration Sites in Host Genomes through Next Generation Sequencing Data

机译:VirusFinder:用于通过下一代测序数据高效准确地检测宿主基因组中的病毒及其整合位点的软件

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摘要

Next generation sequencing (NGS) technologies allow us to explore virus interactions with host genomes that lead to carcinogenesis or other diseases; however, this effort is largely hindered by the dearth of efficient computational tools. Here, we present a new tool, VirusFinder, for the identification of viruses and their integration sites in host genomes using NGS data, including whole transcriptome sequencing (RNA-Seq), whole genome sequencing (WGS), and targeted sequencing data. VirusFinder’s unique features include the characterization of insertion loci of virus of arbitrary type in the host genome and high accuracy and computational efficiency as a result of its well-designed pipeline. The source code as well as additional data of VirusFinder is publicly available at .
机译:下一代测序(NGS)技术使我们能够探索病毒与宿主基因组的相互作用,从而导致致癌或其他疾病。但是,由于缺乏有效的计算工具,因此在很大程度上阻碍了这项工作。在这里,我们提供了一个新工具VirusFinder,用于使用NGS数据识别宿主基因组中的病毒及其整合位点,包括全转录组测序(RNA-Seq),全基因组测序(WGS)和靶向测序数据。 VirusFinder的独特功能包括表征宿主基因组中任意类型病毒的插入基因座,以及经过精心设计的管线,从而具有很高的准确性和计算效率。 VirusFinder的源代码和其他数据可从公开获得。

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