首页> 美国卫生研究院文献>other >Influence of APOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderly
【2h】

Influence of APOE Genotype on Whole-Brain Functional Networks in Cognitively Normal Elderly

机译:APOE基因型对认知正常老年人全脑功能网络的影响

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

This study aimed to investigate the influence of apolipoprotein E (APOE) ε4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE ε4 carriers (ε4+) and 58 non-carriers (ε4-)] underwent clinical evaluation and resting [18F] fluorodeoxyglucose positron emission tomography scan. Whole-brain functional networks were constructed from correlations of the 90 regions of interest using the automated anatomical labeling template, and analyzed using graph theoretical approaches. The overall small-world property seen in ε4- was preserved in ε4+. However, both local clustering and path length were lower in ε4+ compared to ε4-. In terms of the hubs of functional networks, ε4+ showed decreased centrality of the right hippocampus but increased centrality of several brain regions associated with the default mode network compared to ε4-. Our results indicate that genetic vulnerability to Alzheimer’s disease may alter whole-brain functional networks even before clinical symptoms appear.
机译:本研究旨在通过将图论分析应用于脑葡萄糖代谢,研究载脂蛋白E(APOE)ε4等位基因对认知正常(CN)老人的全脑功能网络的影响。对86名CN老年人[28名APOEε4携带者(ε4+)和58名非携带者(ε4-)]进行了临床评估,并静息[ 18 F]氟脱氧葡萄糖正电子发射断层扫描。使用自动解剖标记模板从90个感兴趣区域的相关性构建全脑功能网络,并使用图论方法进行分析。在ε4-中看到的整体小世界性质保留在ε4+中。但是,与ε4-相比,ε4+中的局部聚类和路径长度均较低。就功能网络的集线器而言,与ε4-相比,ε4+显示右海马的中枢性降低,但与默认模式网络相关的几个大脑区域的中枢性增强。我们的结果表明,即使在出现临床症状之前,对阿尔茨海默氏病的遗传易感性也可能会改变全脑功能网络。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号