首页> 美国卫生研究院文献>other >VolRoverN: Enhancing surface and volumetric reconstruction for realistic dynamical simulation of cellular and subcellular function
【2h】

VolRoverN: Enhancing surface and volumetric reconstruction for realistic dynamical simulation of cellular and subcellular function

机译:VolRoverN:增强表面和体积重建以逼真的动态模拟细胞和亚细胞功能

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Establishing meaningful relationships between cellular structure and function requires accurate morphological reconstructions. In particular, there is an unmet need for high quality surface reconstructions to model subcellular and synaptic interactions among neurons at nanometer resolution. We address this need with VolRoverN, a software package that produces accurate, efficient, and automated 3D surface reconstructions from stacked 2D contour tracings. While many techniques and tools have been developed in the past for 3D visualization of cellular structure, the reconstructions from VolRoverN meet specific quality criteria that are important for dynamical simulations. These criteria include manifoldness, water-tightness, lack of self- and object-object-intersections, and geometric accuracy. These enhanced surface reconstructions are readily extensible to any cell type (including glia) and are used here on complex spiny dendrites and axons from mature rat hippocampal area CA1. Both spatially realistic surface reconstructions and reduced skeletonizations are produced and formatted by VolRoverN for easy input into analysis software packages for neurophysiological simulations at multiple spatial and temporal scales ranging from ion electro-diffusion to electrical cable models.
机译:在细胞结构和功能之间建立有意义的关系需要准确的形态重建。特别地,对于以纳米分辨率模拟神经元之间的亚细胞和突触相互作用的高质量表面重建存在未满足的需求。我们使用VolRoverN解决了这一需求,该软件包可以根据堆叠的2D轮廓跟踪生成准确,高效和自动化的3D表面重建。尽管过去已经开发出许多技术和工具来对细胞结构进行3D可视化,但VolRoverN的重建物满足了对于动态仿真非常重要的特定质量标准。这些标准包括流线性,水密性,缺乏自相交和物体与物体的相交以及几何精度。这些增强的表面重建可轻松扩展到任何细胞类型(包括神经胶质细胞),并在这里用于成熟大鼠海马区CA1的复杂棘突树突和轴突。 VolRoverN生成并格式化了空间逼真的表面重构和简化的骨架,以便轻松地将其输入分析软件包中,以进行从离子电扩散到电缆模型的多个时空尺度的神经生理学模拟。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号