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The biology of APOL1 with insights into the association of APOL1 variants with chronic kidney disease

机译：APOL1的生物学深入了解APOL1变体与慢性肾脏疾病的关联

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摘要

Recent studies have identified genetic variants in APOL1 that may contribute to the increased incidence of kidney disease in populations with African ancestry. Herein, we review the biology of APOL1 present in the circulation and localized to the kidney as it may contribute to the pathogenesis of APOL1 associated kidney disease.

机译：最近的研究已经发现APOL1中的遗传变异可能会导致非洲裔人口中肾脏疾病的发生率增加。本文中，我们综述了存在于循环系统中并位于肾脏的APOL1的生物学特性，因为它可能与APOL1相关的肾脏疾病的发病机理有关。

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期刊名称 other
作者
Sethu Madhavan; John F. OToole;
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年(卷),期 -1(18),2
年度 -1
页码 238–242
总页数 8
原文格式 PDF
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关键词
Genetics apolipoprotein HDL APOL1 kidney focal segmental glomerulosclerosis HIV HIV associated neprhopathy hypertensive nephrosclerosis chronic kidney disease;

机译：遗传学;载脂蛋白;HDL;APOL1;肾脏;局灶性节段性肾小球硬化;HIV;HIV相关性肾病;高血压性肾硬化;慢性肾脏病;

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专利

1. The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease [J] . MadhavanS.M., OTooleJ.F. Clinical and experimental nephrology . 2014 ,第2期

机译：APOL1生物学，深入了解APOL1变体与慢性肾脏疾病之间的关联
2. Apol1 nephropathy risk variant associations with diseases beyond the kidney apol1 and sepsis [J] . Ma, L., Freedman, Clinical journal of the American Society of Nephrology: CJASN . 2019 ,第12期

机译：Apol1肾病风险变异与肾脏APOL1和败血症之外的疾病
3. APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans [J] . Tandi E Matsha, Andre P Kengne, Katya L Masconi, BMC Genetics . 2015 ,第1期

机译：南非混合血统中的APOL1基因变异，慢性肾脏疾病和高血压
4. MALDI Biotyper Analysis of Microorganisms Present in Saliva of Chronic Kidney Disease Individuals and their Association with Periodontal Disease [C] . Levy Anderson C Alves, Taciana Mara Couto, Ana Lidia Ciamponi, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：慢性肾病患者唾液中的微生物的MALDI生物脂肪分析及其与牙周病的关联
5. New insights into the molecular regulation of kidney disease: Contributions of APOL1 and MYH9. [D] . Bondzie, Philip Apraku. 2014

机译：肾脏疾病分子调控的新见解：APOL1和MYH9的贡献。
6. APOL1 genetic variants chronic kidney diseases and hypertension in mixed ancestry South Africans [O] . Tandi E Matsha, Andre P Kengne, Katya L Masconi, 2015

机译：南非混合血统中的APOL1基因变异慢性肾脏疾病和高血压
7. The biology of APOL1 with insights into the association between APOL1 variants and chronic kidney disease [O] . Sethu M. Madhavan, John F. O’Toole 2013

机译：APOL1的生物学与APOL1变体与慢性肾病之间的关联有见解
8. APOL1 Oligomerization as the Key Mediator of Kidney Disease in African Americans. [R] . Friedman, D. 2016

机译：apOL1寡聚化作为非洲裔美国人肾脏疾病的关键调节因子。

The biology of APOL1 with insights into the association of APOL1 variants with chronic kidney disease

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