The purpose of the present study was to investigate the effect of nanoemulsions as a carrier vehicle of hydrophilic drug for transdermal delivery. The response surface methodology with a mixture design was used to evaluate the effect of ingredient levels of nanoemulsion formulations including cosurfactant (isopropyl alcohol, 20∼30%), surfactant (mixed of Brij 30 and Brij 35, 20∼30%), and distilled-water (34.5∼50.0%) on properties of the drug-loaded nanoemulsions including physicochemical characters and drug permeability through rat skin. The result showed that the hydrophilic drug in aqueous solution with or without penetration enhancer could not transport across rat skin after 12 h of application. Used nanoemulsions as carrier vehicle, the permeation rate of drug was significantly increased from 0 to 63.23 µg/cm2/h and the lag time was shortened from more than 12 h to about 2.7∼4.0 h. Moreover, the drug-loaded nanoemulsion formulation also showed physicochemical stability after 3 month storage at 25°C and 40°C.
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机译：本研究的目的是研究纳米乳剂作为亲水性药物经皮递送的载体的作用。使用具有混合设计的响应面方法来评估包括辅助表面活性剂（异丙醇，20〜30％），表面活性剂（Brij 30和Brij 35的混合物，20〜30％）和蒸馏的纳米乳剂配方的成分水平的影响-水（34.5％〜50.0％）对载药纳米乳剂的性能，包括理化特性和药物通过大鼠皮肤的渗透性。结果表明，含有或不含渗透促进剂的水溶液中的亲水性药物在使用12小时后均无法在大鼠皮肤上运输。使用纳米乳作为载体，药物的渗透率从0提高到63.23 µg / cm 2 / h，滞后时间从12h以上缩短到2.7〜4.0h。此外，载有药物的纳米乳液制剂在25°C和40°C下储存3个月后也显示出理化稳定性。
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