NANOEMULSION SYSTEM FOR TRANSDERMAL DELIVERY OF PHARMACEUTICAL COMPOSITIONS AND OTHER ACTIVE AGENTS

摘要

A nanoemulsion system for transdermal delivery of a pharmaceutical composition or other active agent across at least an outer layer of skin of a patient includes a first phase, a second phase, and a third phase, and at least one pharmaceutical composition or other active agent. The first phase comprises an oil phase, the second phase comprises an aqueous phase, and the third phase comprises a final phase including a preservation agent. A method of preparing a nanoemulsion system for transdermal delivery of at least one pharmaceutical composition or other active agent across at least an outer layer of skin of a patient includes preparing predetermined amounts of first, second and third phases, heating and combining the first and second phases while stirring, cooling the initial mixture prior to adding the third phase, and cooling the resultant mixture to a final temperature while stirring to form the nanoemulsion system.