A generalized matching law analysis of cocaine vs. food choice in rhesus monkeys: Effects of candidate ‘agonist-based’ medications on sensitivity to reinforcement

摘要

BackgroundWe have previously demonstrated reductions in cocaine choice produced by either continuous 14-day phendimetrazine and D-amphetamine treatment or removing cocaine availability under a cocaine vs. food choice procedure in rhesus monkeys. The aim of the present investigation was to apply the concatenated generalized matching law (GML) to cocaine vs. food choice dose-effect functions incorporating sensitivity to both the relative magnitude and price of each reinforcer. Our goal was to determine potential behavioral mechanisms underlying pharmacological treatment efficacy to decrease cocaine choice.