New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge

摘要

Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (>1a, 2a, 3a, 4, 5), known plakortides (>6,7), known bicyclic lactone (>8) and new cyclic peroxide acids (>1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.