>Brain-specific >angiogenesis >inhibitor 1 (BAI1)->associated >protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell morphogenesis and migration. BAIAP2L1 is recently reported to promote cell proliferation through activation of the EGFR-ERK pathway in hepatocellular carcinoma. In this study, we report the first comprehensive study of BAIAP2L1 upregulation in human ovarian cancer. Upregulation of BAIAP2L1 in ovarian tumors was first found during RNA screening and confirmed by immunohistochemical studies on ovarian cancers and other cancer types. Significant upregulation of BAIAP2L1 in ovarian cancer was validated by analyzing multiple independent cohorts in publicly available data sets. Furthermore, BAIAP2L1 protein expression in metastatic lesions was higher than the corresponding primary tumors. Functional assays in ovarian cancer cells revealed that BAIAP2L1 is involved in promoting cell proliferation and avoiding apoptosis. In conclusion, results of this study not only indicate that BAIAP2L1 can be used as a biomarker for human ovarian cancer but also reveal its role in cancer biology. Further elucidation of the role of BAIAP2L1 in context of the insulin receptor signaling pathways of cancer cells is warranted for developing cancer therapeutics by targeting cancer-specific metabolism.
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机译:> B strong>雨水特异性> a strong>血管生成> i strong>抑制子1(BAI1)-> a strong>关联的> p strong类肌钙蛋白1(BAIAP2L1),也称为胰岛素受体酪氨酸激酶底物(IRTKS),在细胞形态发生和迁移过程中参与质膜突出和肌动蛋白形成。最近报道,BAIAP2L1通过激活肝细胞癌中的EGFR-ERK途径来促进细胞增殖。在这项研究中,我们报告了人类卵巢癌中BAIAP2L1上调的首次综合研究。卵巢肿瘤中BAIAP2L1的上调首先是在RNA筛选期间发现的,并已通过对卵巢癌和其他类型癌症的免疫组织化学研究证实。通过分析公开数据集中的多个独立队列,验证了BAIAP2L1在卵巢癌中的显着上调。此外,BAIAP2L1蛋白在转移性病变中的表达高于相应的原发性肿瘤。卵巢癌细胞中的功能测定表明BAIAP2L1参与促进细胞增殖和避免细胞凋亡。总之,这项研究的结果不仅表明BAIAP2L1可以用作人类卵巢癌的生物标志物,而且还揭示了其在癌症生物学中的作用。为了通过靶向癌症特异性代谢来开发癌症治疗剂,有必要进一步阐明BAIAP2L1在癌细胞的胰岛素受体信号通路中的作用。
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