Disruption of the Rag-Ragulator complex by c17orf59 inhibits mTORC1

摘要

Amino acids induce recruitment of mTORC1 to the lysosomal surface through the Rag GTPases, which are tethered to the lysosomal membrane by Ragulator. c17orf59 interacts with Ragulator, and overexpression disrupts the Rag-Ragulator complex, preventing Rag lysosomal localization and leading to a failure to recruit mTORC1 in the presence of amino acids.