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A Randomized Study of Peginterferon Lambda-1a Compared to Peginterferon Alfa-2a in Combination with Ribavirin and Telaprevir in Patients with Genotype-1 Chronic Hepatitis C

机译：Peginterferon Lambda-1a与Peginterferon Alfa-2a联合利巴韦林和替拉普韦治疗1型慢性丙型肝炎的随机对照研究

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BackgroundA randomized, double-blind, multinational, phase 3 study was conducted comparing the efficacy and safety of peginterferon lambda-1a (Lambda)/ribavirin (RBV)/telaprevir (TVR) vs. peginterferon alfa-2a (Alfa)/RBV/TVR in patients with chronic hepatitis C virus (HCV) genotype-1 (GT-1) infection.

机译：背景进行了一项随机，双盲，跨国的3期研究，比较了聚乙二醇干扰素lambda-1a（Lambda）/利巴韦林（RBV）/ telaprevir（TVR）与聚乙二醇干扰素alfa-2a（Alfa）/ RBV / TVR的疗效和安全性慢性丙型肝炎病毒（HCV）基因型1（GT-1）感染的患者。

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期刊名称 other
作者
Robert Flisiak; Mitchell Shiffman; Juan Arenas; Hugo Cheinquer; Igor Nikitin; Yuping Dong; Khurram Rana; Subasree Srinivasan;
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年(卷),期 -1(11),10
年度 -1
页码 e0164563
总页数 12
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专利

1. Peginterferon Lambda-1a/Ribavirin with Daclatasvir or Peginterferon Alfa-2a/Ribavirin with Telaprevir for Chronic Hepatitis C Genotype 1b [J] . Flisiak Robert, Kawazoe Seiji, Znoyko Olga, Journal of interferon and cytokine research: The official journal of the International Society for Interferon and Cytokine Research . 2016,第11期

机译：Peginterferon Lambda-1a /利巴韦林与达卡他韦或Peginterferon Alfa-2a /利巴韦林与替拉普韦治疗慢性丙型肝炎基因型1b
2. A randomized, open-label, multicenter study evaluating the efficacy of peginterferon alfa-2a versus interferon alfa-2a, in combination with ribavirin, in naive and relapsed chronic hepatitis C patients. [J] . Nevens E, Van Vlierberghe H, DHeygere E, Acta gastro-enterologica Belgica . 2010,第2期

机译：一项随机，开放标签，多中心研究，评估了聚乙二醇干扰素α-2a与干扰素α-2a联合利巴韦林在未治疗和复发的慢性丙型肝炎患者中的疗效。
3. Daclatasvir/peginterferon lambda-1a/ribavirin in patients with chronic HCV infection and haemophilia who are treatment naive or prior relapsers to peginterferon alfa-2a/ribavirin [J] . Santagostino E., Pol S., Olveira A., Haemophilia: the official journal of the World Federation of Hemophilia . 2016,第5期

机译：达格拉他韦/聚乙二醇干扰素lambda-1a /利巴韦林用于慢性HCV感染和血友病的患者，他们是初次或先前复发于聚乙二醇干扰素α-2a/利巴韦林的患者
4. Predictability of Sustained Virological Response (SVR) in Patients with HCV/HIV Co-infection During Combination Therapy With Peginterferon Alfa-2A (40KD) (PEGASYS~R) Plus Ribavirin (COPEGUS~R) in the APRICOT Trial [C] . M. Rodriguez Torres, F.J. Torriani, E. Lissen International AIDS Conference . 2004

机译：HCV / HIV与Peginterferon Alfa-2a（40KD）（Pegasys〜R）加上利韦韦林（Copegus〜R）在杏试验期间HCV / HIV CONOMENT患者持续病毒学反应（SVR）的可预测性
5. Population pharmacokinetics and efficacy of ribavirin in patients with chronic hepatitis C genotype 1 infection. [D] . Jin, Runyan. 2010

机译：利巴韦林在慢性丙型肝炎基因型1感染患者中的群体药代动力学和功效。
6. Mericitabine and Either Boceprevir or Telaprevir in Combination with Peginterferon Alfa-2a plus Ribavirin for Patients with Chronic Hepatitis C Genotype 1 Infection and Prior Null Response: The Randomized DYNAMO 1 and DYNAMO 2 Studies [O] . Heiner Wedemeyer, Xavier Forns, Christophe Hézode, 2011

机译：Mericitabine和Boceprevir或Telaprevir与Peginterferon Alfa-2a加Ribavirin联合治疗慢性丙型肝炎基因1型感染和先前无效反应的患者：DYNAMO 1和DYNAMO 2随机研究
7. A Randomized Study of Peginterferon Lambda-1a Compared to Peginterferon Alfa-2a in Combination with Ribavirin and Telaprevir in Patients with Genotype-1 Chronic Hepatitis C. [O] . Robert Flisiak, Mitchell Shiffman, Juan Arenas, 2016

机译：聚乙二醇干扰素Lambda-1a与聚乙二醇干扰素α-2a联合利巴韦林和Telaprevir治疗基因型-1慢性丙型肝炎的随机对照研究

A Randomized Study of Peginterferon Lambda-1a Compared to Peginterferon Alfa-2a in Combination with Ribavirin and Telaprevir in Patients with Genotype-1 Chronic Hepatitis C

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