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FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity

机译：FOXP3 + Treg作为促进抗肿瘤免疫力的治疗靶标

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IntroductionRegulatory T cells (Treg) characterized by expression of FOXP3 and strong immunosuppressive activity play a key role in regulating homeostasis in health and disease.

机译：简介以FOXP3表达和强大的免疫抑制活性为特征的调节性T细胞（Treg）在调节健康和疾病中的稳态方面起着关键作用。

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期刊名称 other
作者
Theresa L. Whiteside;
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作者单位

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年(卷),期 -1(22),4
年度 -1
页码 353–363
总页数 27
原文格式 PDF
正文语种
中图分类
关键词
Regulatory T cells (Treg) tumor microenvironment (TME) cancer Treg phenotype Treg suppressor functions Treg and checkpoint inhibition;

机译：调节性T细胞（Treg）;肿瘤微环境（TME）;癌症;Treg表型;Treg抑制功能;Treg和检查点抑制;

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专利

1. FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity? [J] . Theresa L. Whiteside Expert opinion on therapeutic targets . 2018,第1a6期

机译：Foxp3 + Treg作为促进抗肿瘤免疫的治疗靶标？
2. Targeting CD4+ CD25+ FOXP3+ Treg cells abrogates established mechanisms of immune tolerance, reshuffles the T cell repertoire and results in effective anti-tumor immunity [J] . S.Rolla, S.Occhipinti, R.Cojoca, European Journal of Cancer Supplements . 2008,第9期

机译：靶向CD4 + CD25 + FOXP3 + Treg细胞可废除已建立的免疫耐受机制，改组T细胞库并产生有效的抗肿瘤免疫力
3. Targeting CD4+ CD25+ FOXP3+ Treg cells abrogates established mechanisms of immune tolerance, reshuffles the T cell repertoire and results in effective anti-tumor immunity [J] . S.Rolla, S.Occhipinti, R.Cojoca, European Journal of Cancer Supplements . 2008,第9期

机译：靶向CD4 + CD25 + FOXP3 + Treg细胞可废除已建立的免疫耐受机制，改组T细胞库并产生有效的抗肿瘤免疫力
4. A Bispecific Antibody Targeting CD40 and CTLA-4 Generates Anti-Tumor Effects and Tumor Immunity [C] . Peter Ellmark, Karin Enell Smith, Niina Veitonmaki, PEGS . 2015

机译：靶向CD40和CTLA-4的双特异性抗体产生抗肿瘤作用和肿瘤免疫力
5. Understanding the Impact of Diet and Obesity on Anti-tumor Immunity and Therapeutic Efficacy in Kidney Cancer [D] . Orlandella, Rachael M. 2020

机译：了解饮食和肥胖对肾癌抗肿瘤免疫和治疗疗效的影响
6. Depletion of FoxP3+ Tregs improves control of larval Echinococcus multilocularis infection by promoting co‐stimulation and Th1/17 immunity [O] . Junhua Wang, Stephan Müller, Renyong Lin, 2017

机译：FoxP3 + Treg的消耗可通过促进共同刺激和Th1 / 17免疫来改善对幼虫棘球E虫感染的控制
7. Site-specific anti-tumor immunity: differences in DC function, TGF-beta production and numbers of intratumoral Foxp3+ Treg [O] . Biollaz, G, Bernasconi, L, Cretton, C, 2009

机译：特定于位点的抗肿瘤免疫力：DC功能，TGF-β产生和肿瘤内Foxp3 + Treg数量的差异

FOXP3+ Treg as a therapeutic target for promoting anti-tumor immunity

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