Formulation and in vitro characterization of domperidone loaded solid lipid nanoparticles and nanostructured lipid carriers

摘要

Background and the purpose of the studyDomperidone (DOM) is a dopamine- receptor (D2) antagonist, widely used in the treatment of motion-sickness. The pharmacokinetic parameters of DOM make it a suitable candidate for development of Solid Lipid Nanoparticle (SLN) and Nanostructured Lipide Carrier (NLC). The purpose of the present investigation was to prepare and evaluate DOM loaded solid lipid nanoparticles (DOM-SLN) and DOM loaded nanostructured lipid carriers (DOM-NLC).