Effects of haloperidol olanzapine ziprasidone and PHA‐543613 on spatial learning and memory in the Morris water maze test in naïve and MK‐801‐treated mice

摘要

IntroductionCognitive impairment is the core symptom of schizophrenia, significantly impacting the functional outcome. Improvement of cognitive function has been an important aspect of the treatment of schizophrenia. Therefore, this study is to demonstrate the effects of first‐generation antipsychotic haloperidol, second‐generation antipsychotic olanzapine and ziprasidone, and alpha‐7 nicotinic acetylcholine receptor agonist PHA‐543613 on spatial learning and memory.