3D absorbed dose distribution estimated by Monte Carlo simulation in radionuclide therapy with a monoclonal antibody targeting synovial sarcoma

摘要

BackroundRadiolabeled OTSA101, a monoclonal antibody targeting synovial sarcoma (SS) developed by OncoTherapy Science, was used to treat relapsing SS metastases following a theranostic procedure: in case of significant ¹¹¹In-OTSA101 tumor uptake and favorable biodistribution, patient was randomly treated with 370/1110 MBq ⁹⁰Y-OTSA101. Monte Carlo-based 3D dosimetry integrating time-activity curves in VOI was performed on ¹¹¹In-OTSA101 repeated SPECT/CT. Estimated absorbed doses (AD) in normal tissues were compared to biological side effects and to the admitted maximal tolerated absorbed dose (MTD) in normal organs. Results in the tumors were also compared to disease evolution.