T152. NRN1 GENE AND FUNCTIONAL MRI: ASSOCIATION ANALYSIS IN SCHIZOPHRENIA PATIENTS AND HEALTHY SUBJECTS

摘要

BackgroundAlterations of synaptic plasticity are currently accepted to play a critical role in schizophrenia (SZ). Among genes of neuronal plasticity there is Neuritin1 gene (NRN1), which has been associated with SZ, age at onset and differences in general cognitive performance in this disorder. However, little is known about the brain imaging correlates of NRN1 gene. We aimed: i) to investigate the association of NRN1 with schizophrenia-spectrum disorders (SZ-SD), exploring its role in age at onset through a family-based study, ii) to examine the brain functional correlates of NRN1 sequence variants through a neuroimaging genetics approach using a case-control design.