Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by 18F-FDG PET

摘要

Tumor glycolytic phenotyping can be accomplished with ¹⁸F-FDG PET. Tumor ¹⁸F-FDG uptake correlates with tumor grade in several cancers. However, the role of ¹⁸F-FDG PET for the grading of soft-tissue sarcomas (STSs) warrants further research.MethodsOne hundred two patients (48 men and 54 women; mean age ± SD, 50 ± 17 y) with 12 STS subtypes underwent ¹⁸F-FDG PET/CT before treatment. Tumor ¹⁸F-FDG uptake, expressed as maximum standardized uptake value (SUVmax), was compared among subtypes and correlated with histopathologic grade. Two frequently used sarcoma grading systems—the 3-tier system of the French Federation of Cancer Centers Sarcoma Group (Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC]) and a 2-tier system (low grade vs. high grade)—were used.