Systemic Delivery of Atropine Sulfate by the MicroDose Dry-Powder Inhaler

机译：微剂量干粉吸入器全身性输送硫酸阿托品

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摘要

BackgroundInhaled atropine is being developed as a systemic and pulmonary treatment for the extended recovery period after chemical weapons exposure. We performed a pharmacokinetics study comparing inhaled atropine delivery using the MicroDose Therapeutx Dry Powder Inhaler (DPIA) with intramuscular (IM) atropine delivery via auto-injector (AUTO).

机译：背景技术吸入式阿托品正被开发为一种全身和肺部治疗方法，可延长化学武器暴露后的恢复期。我们进行了药代动力学研究，比较了使用MicroDose Therapeutx干粉吸入器（DPIA）吸入的阿托品与通过自动注射器（AUTO）进行的肌肉内（IM）阿托品的递送。

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期刊名称 Journal of Aerosol Medicine and Pulmonary Drug Delivery
作者
T.E. Corcoran; R. Venkataramanan; R.M. Hoffman; M.P. George; A. Petrov; T. Richards; S. Zhang; J. Choi; Y.Y. Gao; C.D. Oakum; R.O. Cook; M. Donahoe;
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年(卷),期 -1(26),1
年度 -1
页码 46–55
总页数 10
原文格式 PDF
正文语种
中图分类呼吸生理学;
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入库时间 2022-08-21 10:52:53

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专利

1. Systemic delivery of atropine sulfate by the microdose dry-powder inhaler [J] . CorcoranT.E., VenkataramananR., HoffmanR.M., Journal of aerosol medicine and pulmonary drug delivery . 2013,第1期

机译：微剂量干粉吸入器全身输送硫酸阿托品
2. An evaluation of the systemic bioavailability of mometasone furoate (MF) after oral inhalation from a MF/formoterol fumarate metered-dose inhaler versus an MF dry-powder inhaler in healthy subjects [J] . KosoglouT., HubbellJ., KantesariaB., Clinical pharmacology in drug development . 2014,第3期

机译：在健康受试者中口服MF /富马酸福莫特罗计量吸入器与MF干粉吸入器口服吸入后，糠酸莫米松（MF）的全身生物利用度评估
3. Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease [J] . Teddy Kosoglou, James Hubbell, Fengjuan Xuan, International Journal of Chronic Obstructive Pulmonary Disease . 2013,第1s期

机译：慢性阻塞性肺疾病患者口服糠酸莫米松/福莫特罗富马酸盐计量吸入器与糠酸莫米松干粉吸入器口服吸入后，糠酸莫米松的全身生物利用度比较
4. Determination of atropine sulfate, aminophylline and vitamin by a spectrophotometric method with the aid of chemometrics [C] . Yanhong Lei International Symposium on Chemical Engineering and Material Properties . 2013

机译：借助于化学计学方法测定分光光度法法测定阿托嘌呤，氨基酚碱和维生素
5. Enhancing the Sublingual Permeability of Atropine Sulfate: Effect of pH and Penetration Enhancers [D] . Bafail, Rawan. 2019

机译：增强阿托哌酸酯的舌下渗透性：pH和渗透增强剂的作用
6. Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease [O] . Teddy Kosoglou, James Hubbell, Fengjuan Xuan, 2013

机译：慢性阻塞性肺疾病患者口服糠酸莫米松/福莫特罗富马酸盐计量吸入器与糠酸莫米松干粉吸入器口服吸入后糠酸莫米松的全身生物利用度比较
7. CONSISTENCY OF DOSE DELIVERY OF FLUTICASONE FUROATE (FF)/UMECLIDINIUM (UMEC)/VILANTEROL (VI) ACROSS PATIENT RELEVANT INHALATION FLOW RATES FROM A DRY-POWDER INHALER (DPI) [O] . David Prime, Melanie Hamilton, Oonagh Patmore 2019

机译：在干粉吸入器（DPI）中，氟基浮选（FF）/ Umeclidinium（FF）/ UMEClidinium（UMEC）/ ulanterol（vi）的剂量递送的一致性递送患者相关的吸入流速（DPI）
8. Cutaneous Blood Flow and Local Sweating after Systemic Atropine Administration, [R] . Kolka, M. A., Stephenson, L. A. 1988

机译：全身阿托品给药后皮肤血流量和局部出汗，

Systemic Delivery of Atropine Sulfate by the MicroDose Dry-Powder Inhaler

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