Cerebrospinal Fluid Biomarkers and Proximity to Diagnosis in Preclinical Familial Alzheimers Disease

摘要

Background/Aims:Biological markers of utility in tracking Alzheimer's disease (AD) during the presymptomatic prodromal phase are important for prevention studies. Changes in cerebrospinal fluid (CSF) levels of 42-amino-acid β-amyloid (Aβ42), total tau protein (t-tau) and phosphorylated tau at residue 181 (p-tau181) during this state are incompletely characterized.